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Home » Characterizing Lengthy COVID: Deep Phenotype of a Advanced Situation

Characterizing Lengthy COVID: Deep Phenotype of a Advanced Situation




Quite a few publications describe the scientific manifestations of post-acute sequelae of SARS-CoV-2 (PASC or “lengthy COVID”), however they’re troublesome to combine due to heterogeneous strategies and the shortage of a typical for denoting the various phenotypic manifestations. Affected person-led research are of explicit significance for understanding the pure historical past of COVID-19, however integration is hampered as a result of they usually use completely different phrases to explain the identical symptom or situation. This important disparity in affected person versus scientific characterization motivated the proposed ontological method to specifying manifestations, which can enhance seize and integration of future lengthy COVID research.


The Human Phenotype Ontology (HPO) is a extensively used customary for alternate and evaluation of phenotypic abnormalities in human illness however has not but been utilized to the evaluation of COVID-19.


We recognized 303 articles printed earlier than April 29, 2021, curated 59 related manuscripts that described scientific manifestations in 81 cohorts three weeks or extra following acute COVID-19, and mapped 287 distinctive scientific findings to HPO phrases. We current layperson synonyms and definitions that can be utilized to hyperlink affected person self-report questionnaires to straightforward medical terminology. Lengthy COVID scientific manifestations aren’t assessed constantly throughout research, and most manifestations have been reported with a variety of synonyms by completely different authors. Throughout a minimum of 10 cohorts, authors reported 31 distinctive scientific options akin to HPO phrases; essentially the most generally reported function was Fatigue (median 45.1%) and the least generally reported was Nausea (median 3.9%), however the reported percentages diversified extensively between research.


Translating lengthy COVID manifestations into computable HPO phrases will enhance evaluation, knowledge seize, and classification of lengthy COVID sufferers. If researchers, clinicians, and sufferers share a standard language, then research might be in contrast/pooled extra successfully. Moreover, mapping lay terminology to HPO will assist sufferers help clinicians and researchers in creating phenotypic characterizations which are computationally accessible, thereby enhancing the stratification, prognosis, and remedy of lengthy COVID.


U24TR002306; UL1TR001439; P30AG024832; GBMF4552; R01HG010067; UL1TR002535; K23HL128909; UL1TR002389; K99GM145411.

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