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Home » JCVI assertion on COVID-19 vaccination of youngsters aged 12 to fifteen years: 3 September 2021

JCVI assertion on COVID-19 vaccination of youngsters aged 12 to fifteen years: 3 September 2021



Some COVID-19 vaccines obtainable within the UK are at present authorised to be used in these aged 12 years and over. The Joint Committee on Vaccination and Immunisation (JCVI) has beforehand suggested a suggestion of first doses of Pfizer-BNT162b2 vaccine to all 16 to 17 12 months olds. Individuals aged 16 and 17 years are transferring in the direction of maturity, greater training and/or the office. Their social behaviour and social mixing patterns are totally different in comparison with kids aged 12 to fifteen years, and all through the pandemic charges of an infection have been persistently greater in 16 to 17 12 months olds in comparison with youthful kids. These aged 16 to 17 years may also present knowledgeable consent for their very own vaccination.

JCVI has additionally beforehand provided recommendation concerning the vaccination of youngsters aged 12 to fifteen years with underlying well being circumstances (see Annex A beneath).

The present replace pertains to JCVI’s evaluation of concerns for the vaccination of youngsters aged 12 to fifteen years who shouldn’t have underlying well being circumstances that put them at elevated threat from COVID-19. A precautionary strategy was agreed given the very low threat of significant illness in these aged 12 to fifteen years with out an underlying well being situation that places them at elevated threat. Given this very low threat, concerns on the potential harms and advantages of vaccination are very finely balanced.


The potential advantages of vaccination in kids and younger folks have been set out within the earlier recommendation (JCVI assertion on COVID-19 vaccination of youngsters and younger folks aged 12 to 17 years: 4 August 2021). Key factors of consideration embody that admission charges in kids with underlying co-morbidities have been considerably greater than these in wholesome kids – proof which prompted recommendation on vaccination of youngsters aged 12 and over who’re at scientific threat. The extent of any oblique advantages is extremely unsure given our present understanding of the affect of vaccination on transmission within the brief and medium time period. Understanding of the present and future position of colleges on wider transmission, as a result of earlier use of non-pharmaceutical interventions, will increase this uncertainty concerning the potential affect of vaccination.

On 26 August, 1 September and a couple of September 2021, JCVI met, in collaboration with consultants from abroad, to evaluation up to date proof regarding the epidemiology of COVID-19 within the UK and security knowledge associated to myocarditis following COVID-19 vaccination within the UK, US and Canada. There’s more and more strong proof of an affiliation between vaccination with mRNA COVID-19 vaccines and myocarditis. This can be a very uncommon adversarial occasion. Accessible knowledge from the US and Canada point out the reporting fee of myocarditis is greater following a second dose of mRNA vaccine, in contrast with the primary dose. No affiliation with prior SARS-CoV2 an infection and myocarditis following vaccination has been recognized.

The obtainable knowledge point out that the scientific manifestations of myocarditis following vaccination are usually self-limiting and resolves inside a short while. Nevertheless, the scientific image is atypical and the medium to long-term (months to years) prognosis, together with the potential for persistence of tissue harm ensuing from irritation, is at present unsure as adequate follow-up time has not but occurred.


This recommendation shouldn’t be based mostly on assessments of vaccine availability, future provide or prices related to supply of a programme. When formulating recommendation in relation to childhood immunisations, JCVI has persistently held that the primary focus of its resolution ought to be the profit to kids and younger folks themselves, weighed in opposition to any potential harms from vaccination to kids and younger folks. In offering its recommendation, JCVI additionally recognises that in relation to childhood immunisation programmes, the UK public locations the next relative worth on security in comparison with advantages.

The obtainable proof signifies that the person well being advantages from COVID-19 vaccination are small in these aged 12 to fifteen years who shouldn’t have underlying well being circumstances which put them prone to extreme COVID-19. The potential dangers from vaccination are additionally small, with stories of post-vaccination myocarditis being very uncommon, however doubtlessly critical and nonetheless within the strategy of being described. Given the rarity of those occasions and the restricted follow-up time of youngsters and younger folks with post-vaccination myocarditis, substantial uncertainty stays concerning the well being dangers related to these adversarial occasions.

Total, the committee is of the opinion that the advantages from vaccination are marginally higher than the potential recognized harms (tables 1 to 4) however acknowledges that there’s appreciable uncertainty concerning the magnitude of the potential harms. The margin of profit, based mostly totally on a well being perspective, is taken into account too small to help recommendation on a common programme of vaccination of in any other case wholesome 12 to 15-year-old kids at the moment. As longer-term knowledge on potential adversarial reactions accrue, higher certainty could permit for a reconsideration of the advantages and harms. Such knowledge is probably not obtainable for a number of months.

JCVI has thought-about commentary from stakeholders on the advantages of vaccination on the operation of colleges and the academic affect of the pandemic on kids and younger folks. JCVI is constituted with experience to permit consideration of the well being advantages and dangers of vaccination and it’s not inside its remit to include in-depth concerns on wider societal impacts, together with academic advantages. The federal government could want to search additional views on the broader societal and academic impacts from the chief medical officers of the 4 nations, with illustration from JCVI in these subsequent discussions.
There’s appreciable uncertainty concerning the affect of vaccination in kids and younger folks on peer-to-peer transmission and transmission within the wider (extremely vaccinated) inhabitants. Estimates from modelling fluctuate considerably, and the committee is of the view that any affect on transmission could also be comparatively small, given the decrease effectiveness of the vaccine in opposition to an infection with the Delta variant.

Supply of a COVID-19 vaccine programme for youngsters and younger folks is prone to be disruptive to training within the brief time period, notably if faculty premises are used for vaccination and there may be potential for a COVID-19 vaccine programme to affect on the effectivity of roll-out of the influenza programme. Hostile reactions to vaccination (similar to fevers) may additionally result in time away from training for some people.

Tables 1 to 4: risk-benefit evaluation of COVID-19 vaccination in these aged 12 to fifteen years who shouldn’t have underlying well being circumstances that improve the danger of significant COVID-19 illness

Desk 1: prevented per million first vaccine doses

Paediatric intensive care unit (PICU) Hospitalisations Paediatric inflammatory multisystem syndrome temporally related to SARS-COV2 an infection (PIMS-TS)
2.39 87.01 15.31

Desk 2: prevented per million second vaccine doses

PICU Hospitalisations PIMS-TS
0.16 5.74 12.67

Desk 3: prevented per course

PICU Hospitalisations PIMS-TS
2.54 92.76 27.72

Desk 4: myocarditis threat per million

First dose Second dose
3 to 17 12 to 34

Annex A: JCVI recommendation on vaccination of youngsters aged 12 to fifteen years with underlying well being circumstances (31 August 2021)

JCVI has reviewed additional UK knowledge on hospital admissions, paediatric intensive care unit (PICU) admissions and deaths in kids aged 12 to fifteen years. For the overwhelming majority of youngsters aged 12 to fifteen years, SARS-CoV2 an infection is asymptomatic or mildly symptomatic, and is self-limiting. Of the only a few kids aged 12 to fifteen years who develop extra extreme sickness requiring hospital attendance, the bulk have underlying well being circumstances.

Within the newest evaluation of UK knowledge from the Royal Faculty of Paediatrics and Little one Well being (RCPCH) along with the NHS England (NHSE) Nationwide Scientific Director for youngsters and younger folks (see the ‘References’ part beneath), estimates of the incidence of PICU admission for youngsters aged 12 to fifteen years with out underlying well being circumstances have been 2 per million, in comparison with over 100 per million for these with underlying well being circumstances. These estimates are imprecise as a result of small variety of kids requiring PICU admission over the course of the pandemic.

Beforehand, JCVI suggested that kids with extreme neuro-disabilities, Down’s Syndrome, underlying circumstances leading to immunosuppression, profound and a number of studying disabilities (PMLD), extreme studying disabilities or who’re on the training incapacity register, ought to be provided COVID-19 vaccination.

Following consideration of the up to date knowledge, JCVI advises that the supply of a course of COVID-19 vaccination ought to be expanded to incorporate kids aged 12 to fifteen years with the next:

  • haematological malignancy
  • sickle cell illness
  • sort 1 diabetes
  • congenital coronary heart illness
  • different well being circumstances as described beneath underneath ‘COVID-19 scientific threat teams for youngsters aged 12 to fifteen years’ (these well being circumstances replicate the basket of diagnoses used within the RCPCH and NHSE analyses talked about above).

Bronchial asthma is without doubt one of the commonest underlying well being circumstances prevalent amongst kids and younger folks. The RCPCH and NHSE evaluation discovered that these with bronchial asthma, as a broad group, weren’t at explicit threat from COVID-19. The British Thoracic Society, in collaboration with tutorial companions, have agreed a consensus view concerning which kids and younger folks with poorly managed bronchial asthma are at greater threat from COVID-19. These folks with poorly managed bronchial asthma ought to be provided a course of COVID-19 vaccination.

It’s recognised that there are a selection of much less widespread circumstances in kids, usually attributable to congenital or metabolic defects, the place respiratory infections of any type can lead to extreme sickness. Scientific judgement would have to be utilized in figuring out these kids, and they need to be provided a course of COVID-19 vaccination as effectively.

A course of COVID-19 vaccination refers to a 2-dose major schedule except the person is severely immunosuppressed when a 3-dose major schedule is suggested in accordance with the newest JCVI recommendation on third major vaccine doses (see the inexperienced e-book, Chapter 14a).

COVID-19 scientific threat teams for youngsters aged 12 to fifteen years

Power respiratory illness:

Consists of these with poorly managed bronchial asthma that requires steady or repeated use of systemic steroids or with earlier exacerbations requiring hospital admission, cystic fibrosis, ciliary dyskinesias and bronchopulmonary dysplasia.

Power coronary heart circumstances:

Haemodynamically important congenital and purchased coronary heart illness, or milder coronary heart illness with different co-morbidity.

Power circumstances of the kidney, liver or digestive system:

Consists of these related to congenital malformations of the organs, metabolic issues and neoplasms, and circumstances such extreme gastro-oesophageal reflux that will predispose to respiratory an infection.

Power neurological illness:

Consists of these with:

  • neuro-disability and/or neuromuscular illness together with cerebral palsy, autism, epilepsy and muscular dystrophy
  • hereditary and degenerative illness of the nervous system or muscle tissue, or different circumstances related to hypoventilation
  • extreme or profound and a number of studying disabilities (PMLD), Down’s syndrome, or these on the training incapacity register
  • neoplasm of the mind

Endocrine issues:

Consists of diabetes mellitus, Addison’s and hypopituitary syndrome.


Immunosuppression attributable to illness or therapy, together with:

  • these present process chemotherapy or radiotherapy, stable organ transplant recipients, bone marrow or stem cell transplant recipients
  • genetic issues affecting the immune system (for instance, deficiencies of IRAK-4 or NEMO, complement dysfunction, SCID)
  • these with haematological malignancy, together with leukaemia and lymphoma
  • these receiving immunosuppressive or immunomodulating organic remedy
  • these handled with or prone to be handled with excessive or reasonable dose corticosteroids
  • these receiving any dose of non-biological oral immune modulating medicine – for instance, methotrexate, azathioprine, 6-mercaptopurine or mycophenolate
  • these with auto-immune ailments who could require long run immunosuppressive remedies

Asplenia or dysfunction of the spleen:

Consists of hereditary spherocytosis, homozygous sickle cell illness and thalassemia main.

Critical genetic abnormalities that have an effect on various methods:

Consists of mitochondrial illness and chromosomal abnormalities.


Deaths in Kids and Younger Individuals in England following SARS-CoV-2 an infection throughout the first pandemic 12 months: a nationwide research utilizing linked necessary baby demise reporting knowledge. C Smith, D Odd, R Harwood, J Ward, M Linney, M Clark, D Hargreaves, SN Ladhani, E Draper, PJ Davis, SE Kenny, E Whittaker, Okay Luyt, RM Viner, LK Fraser. medRxiv 2021.07.07.21259779. doi:

Which kids and younger individuals are at greater threat of extreme illness and demise after SARS-CoV-2 an infection: a scientific evaluation and particular person affected person meta-analysis. R Harwood, H Yan, N Talawila Da Camara, C Smith, J Ward, C Tudur-Smith, M Linney, M Clark, E Whittaker, D Saatci, PJ Davis, Okay Luyt, ES Draper, S Kenny, L Okay Fraser, R.M Viner. medRxiv 2021.06.30.21259763. doi:

Threat components for intensive care admission and demise amongst kids and younger folks admitted to hospital with COVID-19 and PIMS-TS in England throughout the first pandemic 12 months. JL Ward, R Harwood, C Smith, S Kenny, M Clark, PJ Davis, ES Draper, D Hargreaves, S Ladhani, M Linney, Okay Luyt, S Turner, E Whittaker, L Okay Fraser, R.M Viner. medRxiv 2021.07.01.21259785; doi:

A few of the knowledge thought-about by JCVI have been unpublished analyses from the research cited above.


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